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Gastroenterology
Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma
Byung Soo Kwan, Jeong Han Kim, Seong Jun Park, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2021;36(2):292-304. Published online April 3, 2020
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC pati..
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Rheumatology
Association of body composition with disease activity and disability in rheumatoid arthritis
Kyeong Min Son, Seong Hun Kang, Young Il Seo, Hyun Ah Kim
Korean J Intern Med. 2021;36(1):214-222. Published online May 15, 2020
Background/Aims: To explore the associations between body composition and pain, disease activity, and disability in rheumatoid arthritis (RA).
Methods: The study enrolled 335 patients with RA and underwent body composition measurement with an InBody analyzer. The associations of body mass index (BM..
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Endocrinology-metabolism
Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls
Chang Seong Kim, Kyung-Do Han, Jin Hyung Jung, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2021;36(1):154-163. Published online June 26, 2019
Background/Aims: Despite recent improvements in the quality of life of patients with systemic lupus erythematosus (SLE), osteoporosis, and osteoporotic fractures are one of the major complications of SLE. Furthermore, limited data are available on the incidence and predictor of osteoporotic fracture..
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Cardiology
Clinical characteristics of spontaneous coronary artery dissection in young female patients with acute myocardial infarction in Korea
Yongcheol Kim, Xiongyi Han, Youngkeun Ahn, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong
Korean J Intern Med. 2021;36(1):106-113. Published online July 18, 2019
Background/Aims: We aimed to evaluate the prevalence, characteristics, and clinical outcomes of spontaneous coronary artery dissection (SCAD) in young female patients with acute myocardial infarction (AMI).
Methods: We identified 8,250 patients diagnosed with AMI who underwent coronary angiogram fr..
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Gastroenterology
Risk for metabolic syndrome in the population with visceral fat area measured by bioelectrical impedance analysis
Han Ho Jeon, Yong Kang Lee, Dong Hyun Kim, Haeyong Pak, Sang Yun Shin, Jeong Hun Seo
Korean J Intern Med. 2021;36(1):97-105. Published online April 29, 2020
Background/Aims: To investigate whether visceral fat area (VFA) measured by bioelectric impedance analysis (BIA) was associated with metabolic syndrome in subjects with and without obesity.
Methods: A total 23,202 participants who underwent medical check-ups were assessed. Participants were stratif..
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The 2020 revision of the guidelines for the management of myeloproliferative neoplasms
Sung-Yong Kim, Sung Hwa Bae, Soo-Mee Bang, Ki-Seong Eom, Junshik Hong, Seongsoo Jang, Chul Won Jung, Hee-Jin Kim, Ho Young Kim, Min Kyoung Kim, Soo-Jeong Kim, Yeung-Chul Mun, Seung-Hyun Nam, Jinny Park, Jong-Ho Won, Chul Won Choi
Korean J Intern Med. 2021;36(1):45-62. Published online December 4, 2020
In 2016, the World Health Organization revised the diagnostic criteria for myeloproliferative neoplasms (MPNs) based on the discovery of disease-driving genetic aberrations and extensive analysis of the clinical characteristics of patients with MPNs. Recent studies have suggested that additional som..
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Gallstone pancreatitis: general clinical approach and the role of endoscopic retrograde cholangiopancreatography
Shanker Kundumadam, Evan L. Fogel, Mark Andrew Gromski
Korean J Intern Med. 2021;36(1):25-31. Published online January 1, 2021
Gallstones account for majority of acute pancreatitis in the Western world. Increase in number and smaller size of the stones increases the risk for biliary pancreatitis. In addition to features of acute pancreatitis, these patients also have cholestatic clinical picture. Fluid therapy and enteral n..
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Rapid Communication
Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
Kyoung-Ho Song, Dong-Min Kim, Hyunju Lee, Sin Young Ham, Sang-Min Oh, Hyeonju Jeong, Jongtak Jung, Chang Kyung Kang, Ji Young Park, Yu Min Kang, Ji-Yeon Kim, Jeong Su Park, Kyoung Un Park, Eu Suk Kim, Hong Bin Kim
Korean J Intern Med. 2021;36(1):11-14. Published online November 25, 2020
Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regardin..
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Original Article
Clinical implication and risk factor of pneumonia development in mild coronavirus disease 2019 patients
Hyun Woo Lee, Seo-Young Yoon, Jung-Kyu Lee, Tae Yeon Park, Deog Kyeom Kim, Hee Soon Chung, Eun Young Heo
Korean J Intern Med. 2021;36(1):1-10. Published online December 1, 2020
Background/Aims: Although a majority of coronavirus disease 2019 (COVID-19) cases were characterized as mild, data assessing the development of pneumonia in mild COVID-19 patients are limited. We aimed to examine the effect of pneumonia development on the clinical course of mild COVID-19 in hospital..
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Infectious diseases
The clinical and economic burden of community-onset complicated skin and skin structure infections in Korea
Yong Kyun Cho, Heung Jeong Woo, Shin Woo Kim, In-Gyu Bae, Young Goo Song, Hee Jin Cheong, Hyuck Lee, Sang Hoon Han, Hee Jung Choi, Chisook Moon, Seong Yeol Ryu, Jian Hur, Ja Cob Lee, Yu Mi Jo, Young Joo Kim
Korean J Intern Med. 2020;35(6):1497-1506. Published online February 20, 2020
Background/Aims: To investigate epidemiologic characteristics, clinical and economic burdens, and factors associated with mortality in complicated skin and skin structure infection (cSSSI) patients in Korea.
Methods: A retrospective, observational, nationwide study was conducted between April to Ju..
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Hemato-oncology
Derivation and validation of modified early warning score plus SpO2/FiO2 score for predicting acute deterioration of patients with hematological malignancies
Ju-Ry Lee, Youn-Kyoung Jung, Hwa Jung Kim, Younsuck Koh, Chae-Man Lim, Sang-Bum Hong, Jin Won Huh
Korean J Intern Med. 2020;35(6):1477-1488. Published online March 3, 2020
Background/Aims: Scoring systems play an important role in predicting intensive care unit (ICU) admission or estimating the risk of death in critically ill patients with hematological malignancies. We evaluated the modified early warning score (MEWS) for predicting ICU admissions and in-hospital mor..
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Pulmonology
Age- and sex-related characteristics of the increasing trend of nontuberculous mycobacteria pulmonary disease in a tertiary hospital in South Korea from 2006 to 2016
Youngmok Park, Chi Young Kim, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2020;35(6):1424-1431. Published online June 19, 2020
Background/Aims: The incidence rate of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide. However, data regarding the age- and sex-specific epidemiology of NTM-PD are limited. This study aimed to investigate the long-term epidemiologic trends of NTM-PD within the recent..
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Gastroenterology
Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han
Korean J Intern Med. 2020;35(6):1354-1363. Published online April 10, 2020
Background/Aims: In Korea, the incidence of colorectal cancer (CRC) and nonalcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC.
Methods: Data from the National Health Ins..
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Nutritional management in patients with chronic kidney disease
Sun Moon Kim, Ji Yong Jung
Korean J Intern Med. 2020;35(6):1279-1290. Published online September 23, 2020
The global prevalence of chronic kidney disease (CKD) is increasing with the aging of populations worldwide. As kidney function declines, the accumulation of metabolic waste products and excessive electrolytes can significantly impair the health of patients with CKD. As nutritional management of pat..
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Geriatrics
Sarcopenia is associated with severe erectile dysfunction in older adults: a population-based cohort study
Hyungchul Park, Il-Young Jang, Minkyu Han, Heayon Lee, Hee-Won Jung, Eunju Lee, Dae Hyun Kim
Korean J Intern Med. 2020;35(5):1245-1253. Published online April 21, 2020
Background/Aims: Sarcopenia and erectile dysfunction (ED) are associat ed with poor health and quality of life in older men. We investigate the association between sarcopenia and severe ED in community-dwelling older men.
Methods: We prospectively assessed sarcopenia and ED in 519, community-dwelli..
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Allergy
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression
Pureun-Haneul Lee, Jisu Hong, An-Soo Jang
Korean J Intern Med. 2020;35(5):1229-1237. Published online February 28, 2020
Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism for tight junctional protein claudin (CLDN) 18 is regulate..
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Infectious diseases
Mediation effect of herpes zoster derived by statin use on cardiovascular disease risk
Sung-Han Kim, Sung-Cheol Yun, Young-Ho Khang, Min-Chul Kim, Sun Uck Kwon, Gyung-Min Park, Young-Rak Cho, Kwang Min Lee, Moo Hyun Kim
Korean J Intern Med. 2020;35(5):1220-1228. Published online June 19, 2020
Background/Aims: Although statins are widely used to reduce the risk of cardiovascular disease (CVD) including stroke and myocardial infarction (MI), it is reported that statin use increases the incidence of herpes zoster (HZ) that is associated with increased risk of CVD. So, we evaluated the media..
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Hemato-oncology
The role of platelet function analyzer-200 in predicting perioperative bleeding risk
Eun Sang Yu, Min Ji Jeon, Ka-Won Kang, Byung-Hyun Lee, Eun Joo Kang, Yong Park, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim, Dae Sik Kim
Korean J Intern Med. 2020;35(5):1199-1209. Published online February 6, 2020
Background/Aims: Various preoperative screening tests, such as platelet count, prothrombin time, activated partial thromboplastin time, and bleeding time, have been widely used to evaluate the risk of bleeding during surgery. Use of platelet function analyzer (PFA)-100/200 for assessing platelet fun..
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Endocrinology-metabolism
The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer
Hee Kyung Kim, Jee Hee Yoon, Jin Seong Cho, Seong Young Kwon, Su Woong Yoo, Ho-Cheol Kang
Korean J Intern Med. 2020;35(5):1164-1172. Published online July 29, 2019
Background/Aims: This study was conducted to identify prognostic factors in patients with papillary thyroid cancer (PTC) at the time of first radioactive iodine (RAI) therapy, and to evaluate the clinical value of the thyroglobulin (Tg) increase after RAI.
Methods: Serum Tg was sampled prior to (pr..
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Pulmonology
Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study
Jaeyoung Cho, Chang-Hoon Lee, Deog Kyeom Kim, Hun-Gyu Hwang, Yu-Il Kim, Hye Sook Choi, Jeong-Woong Park, Kwang Ha Yoo, Ki-Suck Jung, Sang-Do Lee; the KOLD and KOCOSS Investigators
Korean J Intern Med. 2020;35(5):1154-1163. Published online February 27, 2020
Background/Aims: Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ..
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